The content presented here was created for an idea contest in broader meaning that includes presentation techniques. This is not a proposal or explanation of a fully scientifically validated method.
Influenza is a dangerous type of infectious disease that accounts for over half a million deaths each year.
Because it is an RNA-single stranded virus, it is prone to gene mutation, resulting in gaining anti-viral drug resistance. Terrifyingly, someday it may develop drug resistance to currently mainstream NA inhibitor drugs, which would be a serious matter in this recent chaos with COVID-19 infection. With the goal to cultivate a new approach to the flu virus, we focused on virus Hemagglutinin. We have studied Sialic acid derivatives on DNA origami substrates that adsorb on Influenza surface Hemagglutinin and Neuraminidase, in order to create molecules that capture the virus. Calculations showed that the molecules would present high adsorption performance against influenza, for most types. We hope that this molecule can be used not only as a treatment for influenza, but also as a medication for other viruses and for virus quantification.
 Paget J, Spreeuwenberg P, Charu V, et al. Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the GLaMOR Project. J Glob Health. 2019;9(2):020421.
©︎ BIOMOD JAPAN OPEN 2020 Team E